Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure

In patients admitted to the ICU for hypoxemic respiratory failure who receive supplemental oxygen, there are conflicting data showing increased or decreased mortality in treated with a lower oxygenation target compared higher target. One meta-analysis showed targets were preferable critically ill patients, but other trials stopped early due an increase lower-oxygenation groups and increases mesenteric ischemia.